Wednesday, April 13, 2011

Heavy Teens at Increased Risk of Heart Disease Years Later

Teenage boys who are even slightly overweight face an increased risk of heart disease later in life, even if they slim down as adults, according to a new study in the New England Journal of Medicine

Regardless of their adult weight, men who were obese as teenagers were nearly seven times more likely than their slimmest peers to be diagnosed with heart disease in their mid-30s, the study found. Heavier-than-average teens whose body mass index was in the normal range were at increased risk as well. (Body mass index, or BMI, is a ratio of height to weight that provides a rough estimate of body fat.)

The good news is that the same was not true of diabetes. A man’s BMI as an adult, but not as a teen, was linked to an increased risk of developing type 2 diabetes, so slimming down by eating right and exercising appears to go a long way toward preventing the onset of the disease, the researchers say. 

“For those who don’t become obese as adults, the risk of diabetes goes down, but for heart disease this is not the case,” says the lead author of the study, Amir Tirosh, MD, an endocrinologist at Brigham and Women’s Hospital, in Boston. “You don’t get rid of the risk just by reducing the weight. The body remembers when we were running around with a higher BMI.”

Current weight and recent weight changes strongly influence the risk of developing type 2 diabetes. By contrast, the findings suggest, the narrowing and hardening of the arteries (atherosclerosis) that characterizes heart disease and often goes hand in hand with obesity—both are aggravated by a poor diet and sedentary lifestyle—is gradual and difficult to reverse, even with weight loss.

It’s important to keep in mind that being overweight is not solely responsible for heart disease or diabetes, says Daniel Marks, MD, a pediatric endocrinologist at Oregon Health and Sciences University, in Portland. Nutrition, exercise, and other lifestyle choices, he says, have a “much greater impact” on risk than body size alone.

Two people with the same BMI can have very different risks for diabetes and heart disease if one of them exercises regularly and the other does not, says Dr. Marks, who was not involved in the new study. “BMI is a proxy marker for poor lifestyle choices,” he explains. “But it’s the lifestyle choices that will get you in the end. We all need to have healthier lifestyles.”

Indeed, even some boys in the study whose BMIs were considered “normal” were at increased risk of heart disease as adults. The Centers for Disease Control and Prevention defines kids and teens with a BMI between the 5th and 85th percentile for their age as normal, but Tirosh and his colleagues found that boys with BMIs as low as the 50th percentile—which equates to a BMI of about 20—were at increased risk.

“For patients at the higher end of the normal range, doctors should be addressing risk factors such as family history of heart disease and smoking,” Dr. Tirosh says.

Source: By Matt McMillen 

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